3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide

Base Information

Chemical Name:3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide
CAS No.:1208067-93-9
Molecular Formula:C₂₈H₂₄Cl₂FN₅O₃S
Molecular Weight:600.501
Hs Code.:

Synonyms:3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide

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Chemical Property of 3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide

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Technology Process of 3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide

There total 4 articles about 3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-12-6
2-aminopyrimidine

: 1161500-83-9
3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid

: 1208067-93-9
3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide

Guidance literature:: 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.75h;

2-aminopyrimidine; With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

: 850807-08-8
5-amino-3-fluorobenzoic acid ethyl ester

: 1208067-93-9
3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / 4-methyl-2-pentanone / 23 h / 20 °C / Reflux

3.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3.2: pH 5

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0.75 h / 20 °C

4.2: 2.5 h / 20 °C

With pyridine; thionyl chloride; water; potassium carbonate; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 4-methyl-2-pentanone;

Reference yield:

: 1161500-82-8
3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

: 1208067-93-9
3-[{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(pyrimidin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

1.2: pH 5

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0.75 h / 20 °C

2.2: 2.5 h / 20 °C

With thionyl chloride; water; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;