carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

Base Information

Chemical Name:carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester
CAS No.:228394-71-6
Molecular Formula:C₃₅H₅₅N₅O₉Si₂
Molecular Weight:746.021
Hs Code.:

carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester <i>tert</i>-butyl ester

Synonyms:carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

There total 5 articles about carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 22129-07-3
N-benzyloxycarbonylimidazole

: 228394-70-5
carbonic acid 5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

: 228394-71-6
carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

Guidance literature:: With 18-crown-6 ether; potassium hydride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/ja990274q

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 228394-71-6
carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / DMAP, Et₃N / dimethylsulfoxide / 4 h / Ambient temperature

2: 97 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 84 percent / KH, 18-crown-6 / tetrahydrofuran / 2 h / Ambient temperature

With 1H-imidazole; dmap; 18-crown-6 ether; potassium hydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja990274q

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 228394-71-6
carbonic acid 5-(2-benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 84 percent / KH, 18-crown-6 / tetrahydrofuran / 2 h / Ambient temperature

With 1H-imidazole; 18-crown-6 ether; potassium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja990274q