3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester

Base Information

Chemical Name:3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester
CAS No.:101836-21-9
Molecular Formula:C₁₃H₁₈O₃S
Molecular Weight:254.35
Hs Code.:

Synonyms:3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester

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Chemical Property of 3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester

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Technology Process of 3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester

There total 3 articles about 3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 85460-73-7
2,3,5-trimethyl-4-hydroxy-benzenethiol

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 101836-21-9
3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester

Guidance literature:: With sulfuric acid; trimethyl orthoformate; In methanol; for 72h; Heating;
DOI:10.1021/jo00360a013

Reference yield:

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 101836-21-9
3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester

Guidance literature:: 2,3,5-trimethyl-4-hydroxy-benzenethiol; With trimethyl orthoformate; In methanol; for 0.833333h;

acrylic acid methyl ester; With sulfuric acid; In methanol; for 48h; Heating / reflux;

Reference yield:

: 101836-20-8
2,3,5-trimethyl-4-hydroxyphenyl thiocyanate

: 101836-21-9
3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2: 64 percent / trimethyl orthoformate, conc. H₂SO₄ / methanol / 72 h / Heating

With lithium aluminium tetrahydride; sulfuric acid; trimethyl orthoformate; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo00360a013