methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate
CAS No.:1146510-36-2
Molecular Formula:C₂₁H₁₉BrO₆
Molecular Weight:447.282
Hs Code.:

Synonyms:methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

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Chemical Property of methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

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Technology Process of methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

There total 1 articles about methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 516-09-6
4-hydroxy-3-methyl-5H-furan-2-one

: 57699-28-2
methyl 4-bromophenylglyoxalate

: 1146510-36-2
methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

Guidance literature:: With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 - -20 ℃;

4-hydroxy-3-methyl-5H-furan-2-one; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

methyl 4-bromophenylglyoxalate; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jm801500h

Reference yield: 66.0%

: 1146510-36-2
methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

: 1350907-85-5
methyl 2-(4-bromophenyl)-2-(3-hydroxy-4-methyl-5-oxofuran-2(5H)-ylidene)acetate

Guidance literature:: With 1% Pd/C; hydrogen; In dichloromethane; at 20 ℃;
DOI:10.1021/jm801500h

Reference yield:

: 1146510-36-2
methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

: methyl 2-(3-(benzyloxy)-4-methyl-5-oxofuran-2(5H)-ylidene)-2-(4-bromo)phenylacetate

: methyl 2-(3-(benzyloxy)-4-methyl-5-oxofuran-2(5H)-ylidene)-2-(4-bromo)phenylacetate

Guidance literature:: methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate; With dmap; triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 12h;

With hydrogenchloride; In dichloromethane; water; optical yield given as %de;
DOI:10.1021/jm801500h