2(5H)-Furanone, 4-hydroxy-3-methyl-

Base Information

• Chemical Name: 2(5H)-Furanone, 4-hydroxy-3-methyl-
• CAS No.: 516-09-6
• Molecular Formula: C5H6O3
• Molecular Weight: 114.101
• Hs Code.: 2932209090
• Mol file: 516-09-6.mol

Synonyms:4-Hydroxy-3-methyl-5H-furan-2-one;2(5H)-Furanone,4-hydroxy-3-methyl;5-hydroxy-4-methylfuran-3-one;

Chemical Property of 2(5H)-Furanone, 4-hydroxy-3-methyl-

Chemical Property:

• Melting Point: 190-191 °C
• Boiling Point: 286.8±40.0 °C(Predicted)
• PKA: 4.01±0.10(Predicted)
• PSA: 46.53000
• Density: 1.382±0.06 g/cm3(Predicted)
• LogP: 0.37520

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-3-methyl-5h-furan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(5H)-Furanone, 4-hydroxy-3-methyl-

There total 3 articles about 2(5H)-Furanone, 4-hydroxy-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

toluene-4-sulfonic acid 4-methyl-5-oxo-2,5-dihydro-furan-3-yl ester (263765-02-2) → 4-toluenesulfonyl azide (941-55-9) + 4-hydroxy-3-methyl-5H-furan-2-one (516-09-6) + 4-azido-3-methyl-5H-furan-2-one

Guidance literature:

With sodium azide; In methanol; at 20 ℃;

DOI:10.1080/00397910008087364

Reference yield:

cyclohexanespiro-2'-(1',3'-dioxolan)-4'-one (4423-79-4) + propanoic acid methyl ester (554-12-1) → 4-hydroxy-3-methyl-5H-furan-2-one (516-09-6) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight;

Reference yield:

cyclohexanespiro-2'-(1',3'-dioxolan)-4'-one (4423-79-4) + tert-butyl propionate (20487-40-5) → 4-hydroxy-3-methyl-5H-furan-2-one (516-09-6) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight;

upstream raw materials:

cyclohexanespiro-2'-(1',3'-dioxolan)-4'-one

propanoic acid methyl ester

tert-butyl propionate

toluene-4-sulfonic acid 4-methyl-5-oxo-2,5-dihydro-furan-3-yl ester

Downstream raw materials:

methyl 2-(3-(benzyloxy)-4-methyl-5-oxo-2.5-dihydrofuran-2-yl)-2-(4-bromophenyl)-2-hydroxyacetate

3-methyl-2H-furo[2,3-c]pyran-2-one

2-((S)-oxiran-2-yl)ethyl 2-((E)-3-(3-methyl-2,4-dioxotetrahydrofuran-3-yl)prop-1-en-1-yl)benzoate

3-cinnamyl-3-methyl-3H,5H-furan-2,4-dione