4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine

Base Information

Chemical Name:4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine
CAS No.:914669-95-7
Molecular Formula:C₂₃H₂₇F₃N₄OS
Molecular Weight:464.555
Hs Code.:

Synonyms:4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine

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Chemical Property of 4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine

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Technology Process of 4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine

There total 6 articles about 4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56026-36-9
methyl 6-(hydroxymethyl)nicotinate

: 914669-95-7
4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dmap / dichloromethane / 5 h / -78 °C

2.1: methanol / 5.5 h / 0 - 20 °C

3.1: sodium hydroxide; water / methanol / 1.5 h / 90 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran; diethyl ether / 0 - 20 °C

5.2: 2 h / 0 °C

6.1: ethanol / 2 h / Heating / reflux

With sodium hydroxide; oxalyl dichloride; water; triethylamine; dmap; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 832099-29-3
1-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiourea

: 1088699-51-7
C₁₀H₁₃ClN₂O

: 914669-95-7
4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine

Guidance literature:: In ethanol; for 2h; Heating / reflux;

Reference yield:

: 588720-36-9
6-(((methylsulfonyl)oxy)methyl)nicotinic acid methyl ester

: 914669-95-7
4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 5.5 h / 0 - 20 °C

2.1: sodium hydroxide; water / methanol / 1.5 h / 90 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 20 °C

4.1: triethylamine / tetrahydrofuran; diethyl ether / 0 - 20 °C

4.2: 2 h / 0 °C

5.1: ethanol / 2 h / Heating / reflux

With sodium hydroxide; oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;