3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

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Chemical Name:3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate
CAS No.:1311286-04-0
Molecular Formula:C₂F₃O₂*C₂HF₃O₂*C₅₅H₆₄N₉O₅S
Molecular Weight:1190.28
Hs Code.:

3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

Synonyms:3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

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Chemical Property of 3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

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Technology Process of 3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

There total 12 articles about 3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1310327-46-8
2-(4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)-3-(4-(2,5-dioxopyrrolidin-1-yloxy)-4-oxobutyl)benzo[d]thiazol-3-ium trifluoroacetate

: (R)-Nω-[(4-aminobutyl)aminocarbonyl]-Nα-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)argininamide bis(hydrotrifluoroacetate)

: 76-05-1
trifluoroacetic acid

: 1311286-04-0
3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

Guidance literature:: 2-(4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)-3-(4-(2,5-dioxopyrrolidin-1-yloxy)-4-oxobutyl)benzo[d]thiazol-3-ium trifluoroacetate; (R)-Nω-[(4-aminobutyl)aminocarbonyl]-Nα-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)argininamide bis(hydrotrifluoroacetate); With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.045

Reference yield:

: 1093677-53-2
(R)-N'-(4-tert-butoxybenzyl)-N^α-(2,2-diphenylacetyl)ornithinamide

: 1311286-04-0
3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: water / dichloromethane / 2 h

3: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With water; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.045

Reference yield:

: 120-75-2
2-Methylbenzothiazole

: 1311286-04-0
3-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 72 h / 110 °C

2: pyridine / methanol / 18 h / Reflux

3: lithium hydroxide / tetrahydrofuran; ethanol; water / 3 h / 20 °C

4: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0 - 20 °C

5: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.045