(S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Base Information

Chemical Name:(S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride
CAS No.:1410809-83-4
Molecular Formula:C₂₁H₂₄N₂O₄*ClH
Molecular Weight:404.894
Hs Code.:

Synonyms:(S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

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Chemical Property of (S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

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Technology Process of (S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

There total 8 articles about (S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1410809-82-3
(S)-methyl 2-(4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-(tert-butoxycarbonylamino)-3-methylbutanoate

: 1410809-83-4
(S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; for 0.166667h;

Reference yield:

: 1410809-78-7,397274-64-5
((1R,2R)-2-formylcyclopropyl)methyl acetate

: 1410809-83-4
(S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

2.1: triethylamine / Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran / 8 h / 20 °C

3.2: pH 4 / Acidic aqueous solution

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: hydrogenchloride / methanol / 0.17 h

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1410809-79-8
((1R,2R)-2-(2,2-dibromovinyl)cyclopropyl)methyl acetate

: 1410809-83-4
(S)-methyl 3-amino-2-(4-(((1 R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 8 h / 20 °C

2.2: pH 4 / Acidic aqueous solution

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

4.1: hydrogenchloride / methanol / 0.17 h

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;