Propargyl-PEG4-CH2CO2tBu

Base Information

• Chemical Name: Propargyl-PEG4-CH2CO2tBu
• CAS No.: 888010-02-4
• Molecular Formula: C₁₅H₂₆O₆
• Molecular Weight: 302.368
• Mol file: 888010-02-4.mol

Synonyms:tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate

Chemical Property of Propargyl-PEG4-CH2CO2tBu

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-PEG4-CH2CO2tBu 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG4-CH2CO2tBu is a PEG reagent that can reacts with azide compounds or biomolecules under the catalyzation of copper. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of Propargyl-PEG4-CH2CO2tBu

There total 4 articles about Propargyl-PEG4-CH2CO2tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate (888010-02-4)

Guidance literature:

With tetrabutyl-ammonium chloride; sodium hydroxide; In dichloromethane; water; at 0 - 20 ℃; for 5h;

Reference yield: 56.0%

tert-Butyl chloroacetate (107-59-5) + O-propargyl triethylene glycol (208827-90-1) → tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate (888010-02-4)

Guidance literature:

O-propargyl triethylene glycol; With sodium hydride; In tetrahydrofuran; at 0 - 25 ℃; for 0.5h; Inert atmosphere;

tert-Butyl chloroacetate; In tetrahydrofuran; at 25 ℃; for 12h; Inert atmosphere;

Reference yield: 53.0%

bromoacetic acid tert-butyl ester (5292-43-3) + O-propargyl triethylene glycol (208827-90-1) → tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate (888010-02-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 25 ℃; for 13h;

DOI:10.1039/b518061a

upstream raw materials:

bromoacetic acid tert-butyl ester

O-propargyl triethylene glycol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

tert-Butyl chloroacetate

Downstream raw materials:

C₃₄H₄₃BF₂N₂O₆

C₃₄H₄₁BF₂I₂N₂O₆

C₅₀H₅₁BF₂N₂O₆

C₅₂H₅₁BF₂N₂O₁₀