(4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

Base Information

Chemical Name:(4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide
CAS No.:216855-31-1
Molecular Formula:C₁₃H₂₁NO₅
Molecular Weight:271.313
Hs Code.:

Synonyms:(4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

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Chemical Property of (4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

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Technology Process of (4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

There total 3 articles about (4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 626-35-7
nitroacetic acid ethyl ester

: 216855-05-9
(2R,3S,4S,5R)-1,6-dicyclohexyl-2,5-di-O-(methanesulfonyl)-2,3,4,5-hexanetetraol

: 216855-31-1
(4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

Guidance literature:: With 1H-imidazole; sodium periodate; In ethanol; water; at 20 ℃;
DOI:10.1021/jo980941i

Reference yield:

: 216854-71-6
(2R,3R,4R,5R)-1,6-dicyclohexyl-3,4-O-isopropylidene-2,3,4,5-hexanetetraol

: 216855-31-1
(4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine; DMAP / 0 - 4 °C

2: 70 percent / conc. HCl / acetic acid / 1 h / 20 °C

3: 100 percent / sodium periodate; imidazole / H₂O; ethanol / 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; sodium periodate; In ethanol; water; acetic acid; 1: Esterification / 2: Hydrolysis / 3: Oxidation;
DOI:10.1021/jo980941i

Reference yield:

: 216854-84-1
(2R,3S,4S,5R)-1,6-dicyclohexyl-3,4-O-isopropylidene-2,5-di-O-(methanesulfonyl)-2,3,4,5-hexanetetraol

: 216855-31-1
(4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / conc. HCl / acetic acid / 1 h / 20 °C

2: 100 percent / sodium periodate; imidazole / H₂O; ethanol / 20 °C

With 1H-imidazole; hydrogenchloride; sodium periodate; In ethanol; water; acetic acid; 1: Hydrolysis / 2: Oxidation;
DOI:10.1021/jo980941i