(4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

Base Information

Chemical Name:(4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide
CAS No.:216855-95-7
Molecular Formula:C₂₉H₃₉NO₅Si
Molecular Weight:509.718
Hs Code.:

Synonyms:(4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

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Technology Process of (4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

There total 1 articles about (4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 216855-31-1
(4RS,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

: 216856-27-8
(4S,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

: 216855-98-0
(4S,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

: 216855-95-7
(4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

Guidance literature:: With dmap; triethylamine; In diethyl ether; at 20 ℃; for 24h;
DOI:10.1021/jo980941i

Reference yield: 70.0%

: 216855-95-7
(4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

: (4R,5S)-5-cyclohexylmethyl-3-ethoxycarbonyl-4-hydroxy-2-isoxazoline 2-oxide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;
DOI:10.1021/jo980941i

Reference yield:

: 216855-95-7
(4R,5S)-4-(t-butyldiphenylsilyloxy)-5-cyclohexylmethyl-3-ethoxycarbonyl-2-isoxazoline 2-oxide

: ethyl (2aS,6S,6aR,6bS)-6-cyclohexylmethyl-2,2-dimethyltetrahydro-2H,6bH-1,4,5-trioxa-4a-aza-2-silacyclopenta[cd]pentalene-6b-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

2: 76 percent / imidazole / CH₂Cl₂ / 24 h

With 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; 1: desilylation / 2: Cyclization;
DOI:10.1021/jo980941i