(3β)-3-O-tert-ButyldiMethylsilyl-cholest-5-ene-3,24-diol

Base Information

Chemical Name:(3β)-3-O-tert-ButyldiMethylsilyl-cholest-5-ene-3,24-diol
CAS No.:84529-86-2
Molecular Formula:C₃₀H₅₄O₂Si
Molecular Weight:474.843
Hs Code.:
Mol file:84529-86-2.mol

Synonyms:(20R)-3β-(tert-butyldimethylsilyloxy)-24-hydroxy-25,26,27-trisnorcholest-5-ene

Suppliers and Price of (3β)-3-O-tert-ButyldiMethylsilyl-cholest-5-ene-3,24-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3β)-3-O-tert-Butyldimethylsilyl-cholest-5-ene-3,24-diol
100mg
$ 1390.00

Total 3 raw suppliers

Chemical Property of (3β)-3-O-tert-ButyldiMethylsilyl-cholest-5-ene-3,24-diol

Chemical Property:

Melting Point:166-168°C
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly, Sonicated)

Purity/Quality:: (3β)-3-O-tert-Butyldimethylsilyl-cholest-5-ene-3,24-diol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3β)-3-O-tert-Butyldimethylsilyl-cholest-5-ene-3,24-diol is a reactant used in the preparation of series of cholesterol side-chain analogs used in studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P 450 enzymes. It is used in the preparation of (25S)-Δ7-dafachronic acid, (25S)-Δ4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid.

Technology Process of (3β)-3-O-tert-ButyldiMethylsilyl-cholest-5-ene-3,24-diol

There total 17 articles about (3β)-3-O-tert-ButyldiMethylsilyl-cholest-5-ene-3,24-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 114011-35-7
3β-(t-butyldimethylsilyloxy)-5-cholenic acid methyl ester

: 84529-86-2
(20R)-3β-(tert-butyldimethylsilyloxy)-24-hydroxy-25,26,27-trisnorcholest-5-ene

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 50 ℃; for 1h; Cooling with ice;

Reference yield: 98.0%

: 1384736-04-2
ethyl (20R)-3β-(tert-butyldimethylsilyloxy)chol-5-en-24-oate

: 84529-86-2
(20R)-3β-(tert-butyldimethylsilyloxy)-24-hydroxy-25,26,27-trisnorcholest-5-ene

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.05.003

Reference yield: 6.0%

: 625-81-0
diisopropyl zinc

: 84529-74-8
(20R)-3β-(tert-butyldimethylsilyloxy)-24-oxo-25,26,27-trisnorcholest-5-ene

: 84529-86-2
(20R)-3β-(tert-butyldimethylsilyloxy)-24-hydroxy-25,26,27-trisnorcholest-5-ene

: 130474-14-5
24-(R)-hydroxycholesterol 3-(O)-tert-butyldimethylsilyl ether

Guidance literature:: With (1S,2R)-(-)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol; In toluene; at 0 ℃; for 24h;
DOI:10.1016/0957-4166(95)00073-X