(R)-1-phenyl-2-(phenylmethoxy)ethylamine

Base Information

• Chemical Name: (R)-1-phenyl-2-(phenylmethoxy)ethylamine
• CAS No.: 162237-91-4
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.306
• Mol file: 162237-91-4.mol

Synonyms:(R)-1-phenyl-2-(phenylmethoxy)ethylamine

Chemical Property of (R)-1-phenyl-2-(phenylmethoxy)ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-phenyl-2-(phenylmethoxy)ethylamine

There total 15 articles about (R)-1-phenyl-2-(phenylmethoxy)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(RS,1R)-2-methylpropane-2-sulfinic acid (2-benzyloxy-1-phenylethyl)amide (342651-78-9) → (R)-1-phenyl-2-(phenylmethoxy)ethylamine (162237-91-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

DOI:10.1016/S0040-4039(01)00122-8

Reference yield: 56.0%

D-2-phenylglycinol (56613-80-0) + benzyl bromide (100-39-0) → (R)-1-phenyl-2-(phenylmethoxy)ethylamine (162237-91-4)

Guidance literature:

D-2-phenylglycinol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

benzyl bromide; In tetrahydrofuran; at 20 - 65 ℃; for 4.16667h; Inert atmosphere;

DOI:10.1039/c1dt10588d

Reference yield:

N,N-diallyl-N-[(1R)-2-(benzyloxy)-1-phenylethyl]amine (860304-25-2) → (R)-1-phenyl-2-(phenylmethoxy)ethylamine (162237-91-4)

Guidance literature:

With Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 12h;

DOI:10.1021/jm0409019

upstream raw materials:

D-2-phenylglycinol

benzyl chloride

(R_S,1R)-2-methylpropane-2-sulfinic acid (2-benzyloxy-1-phenylethyl)amide

(R)-3-Benzyloxy-2-phenyl-propionamide

Downstream raw materials:

tert-butyl (3aR,4R,6aS)-4-({[(1R)-2-(benzyloxy)-1-phenylethyl]amino}methyl)-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate

Boc-D-Phg-OH

(R)-phenylglycine hydrochloride

(R)-N-(tert-butoxycarbonyl)phenylglycinol