(5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid

Base Information

Chemical Name:(5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid
CAS No.:1073318-20-3
Molecular Formula:C₁₆H₁₅BrFN₅O₅
Molecular Weight:456.228
Hs Code.:

Synonyms:(5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid

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Chemical Property of (5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid

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Technology Process of (5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid

There total 7 articles about (5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073319-30-8
ethyl (5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetate

: 1073318-20-3
(5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.0833333h;
DOI:10.1016/j.bmcl.2011.10.070

Reference yield:

: 1367486-21-2
C₁₄H₁₂BrFN₂O₃

: 1073318-20-3
(5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; pyridine hydrochloride / 1-methyl-pyrrolidin-2-one / 125 - 140 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 90 °C

3: methanol; sodium hydroxide / tetrahydrofuran / 0.08 h / 20 °C

With methanol; sodium azide; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one;
DOI:10.1016/j.bmcl.2011.10.070

Reference yield:

: C₁₄H₁₄BrFN₂O₄

: 1073318-20-3
(5-{3-[4-(2-bromo-5-fluorophenoxy)butoxy]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

2: sodium azide; pyridine hydrochloride / 1-methyl-pyrrolidin-2-one / 125 - 140 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 90 °C

4: methanol; sodium hydroxide / tetrahydrofuran / 0.08 h / 20 °C

With methanol; sodium azide; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/j.bmcl.2011.10.070