5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI)

Base Information

• Chemical Name: 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI)
• CAS No.: 108990-72-3
• Molecular Formula: C₇H₉N₃
• Molecular Weight: 135.169
• Hs Code.: 2933990090
• Mol file: 108990-72-3.mol

Synonyms:5H-Cyclopentapyrimidine,2-amino-6,7-dihydro- (6CI); NSC 28096

Chemical Property of 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI)

Chemical Property:

• Vapor Pressure: 4.8E-05mmHg at 25°C
• Refractive Index: 1.644
• Boiling Point: 349.1oC at 760 mmHg
• Flash Point: 191.9oC
• PSA: 51.80000
• Density: 1.26g/cm3
• LogP: 1.12870

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dihydro-5H-cyclopenta[d]pyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI)

There total 8 articles about 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-chlorocyclopent-1-ene-1-carbaldehyde (2611-03-2) + guanidine hydrochloride (50-01-1) → 6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-amine (108990-72-3)

Guidance literature:

With potassium carbonate; In methanol; Reflux;

DOI:10.1002/ejoc.201700737

Reference yield:

4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-amine (5461-89-2) → 6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-amine (108990-72-3)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation_.unter Zusatz von MgO;

DOI:10.1021/ja01521a049

Reference yield:

2-amino-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one (33081-06-0) → 6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-amine (108990-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃

2: ethanol

3: Raney nickel; H₂O

With ethanol; water; nickel; trichlorophosphate;

DOI:10.1021/ja01521a049

upstream raw materials:

4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-amine

2-amino-3,5,6,7-tetrahydro-cyclopentapyrimidine-4-thione

2-formylcyclopentanone

diguanidine carbonate

Refernces