α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate

Base Information

Chemical Name:α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate
CAS No.:925705-09-5
Molecular Formula:C₃₂H₃₈FN₃O₆S
Molecular Weight:611.735
Hs Code.:

Synonyms:α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate

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Chemical Property of α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate

Chemical Property:

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Technology Process of α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate

There total 2 articles about α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925421-90-5
α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

: 925705-09-5
α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate

Guidance literature:: With triethylamine tris(hydrogen fluoride); In water; tert-butyl alcohol; at 50 ℃; for 4h; Product distribution / selectivity;

Reference yield:

: 925421-76-7
methyl (3S,E)-5-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-3-tert-butyldimethylsilyloxy-pent-4-enoate

: 151-05-3
1,1-dimethyl-2-phenylethyl acetate

: 925705-09-5
α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate

Guidance literature:: 1,1-dimethyl-2-phenylethyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -70 - -60 ℃; for 0.5h;

methyl (3S,E)-5-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-3-tert-butyldimethylsilyloxy-pent-4-enoate; With tert-butylmagnesium chloride; In tetrahydrofuran; n-heptane; ethylbenzene; at -60 - 20 ℃; for 2h;

With acetic acid; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; for 8h; Product distribution / selectivity;

Reference yield:

: 925705-09-5
α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate

: 925705-14-2
rosuvastatin α,α-dimethylphenethyl ester

Guidance literature:: α,α-dimethylphenethyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidine-5-yl)-5-hydroxy-3-oxo-hept-6-enoate; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -80 ℃; for 0.333333h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -80 ℃; for 4h;

With sodium hydrogencarbonate; acetic acid; more than 3 stages;