Azepino[2,1-b]quinazolin-12(6H)-one, 7,8,9,10-tetrahydro-4-hydroxy-

Base Information

• Chemical Name: Azepino[2,1-b]quinazolin-12(6H)-one, 7,8,9,10-tetrahydro-4-hydroxy-
• CAS No.: 108937-88-8
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.266
• Hs Code.: 2933990090
• Mol file: 108937-88-8.mol

Synonyms:Azepino[2,1-b]quinazolin-12(6H)-one, 7,8,9,10-tetrahydro-4-hydroxy-

Chemical Property of Azepino[2,1-b]quinazolin-12(6H)-one, 7,8,9,10-tetrahydro-4-hydroxy-

Chemical Property:

• PSA: 55.12000
• LogP: 1.82850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Azepino[2,1-b]quinazolin-12(6H)-one, 7,8,9,10-tetrahydro-4-hydroxy-

There total 3 articles about Azepino[2,1-b]quinazolin-12(6H)-one, 7,8,9,10-tetrahydro-4-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

8-methoxy-3,4-dihydro-2,3-pentamethylenequinazolone (61938-74-7) → 8-hydroxy-3,4-dihydro-2,3-pentamethylenequinazolone (108937-88-8)

Guidance literature:

With hydrogen bromide; Heating;

DOI:10.1007/BF00579819

Reference yield:

caprolactam (105-60-2,9012-16-2) → 8-hydroxy-3,4-dihydro-2,3-pentamethylenequinazolone (108937-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.5 g / POCl₃ / toluene / 3 h / 100 °C

2: 80 percent / 47percent HBr / Heating

With hydrogen bromide; trichlorophosphate; In toluene;

DOI:10.1007/BF00579819

Reference yield:

2-amino-3-methoxybenzoic acid hydrochloride (68701-23-5) → 8-hydroxy-3,4-dihydro-2,3-pentamethylenequinazolone (108937-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.5 g / POCl₃ / toluene / 3 h / 100 °C

2: 80 percent / 47percent HBr / Heating

With hydrogen bromide; trichlorophosphate; In toluene;

DOI:10.1007/BF00579819

upstream raw materials:

8-methoxy-3,4-dihydro-2,3-pentamethylenequinazolone

caprolactam

2-amino-3-methoxybenzoic acid hydrochloride