methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate

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Chemical Name:methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate
CAS No.:175210-52-3
Molecular Formula:C₁₇H₁₈N₂O₅
Molecular Weight:330.34
Hs Code.:

Synonyms:methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate

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Chemical Property of methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate

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Technology Process of methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate

There total 3 articles about methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 147269-67-8
3-(benzyloxycarbonylamino)pyrid-2-one

: 115724-80-6
(R)-2-trifluoromethanesulfonyloxy-propionic acid methyl ester

: 175210-52-3
methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate

Guidance literature:: 3-(benzyloxycarbonylamino)pyrid-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

(R)-2-trifluoromethanesulfonyloxy-propionic acid methyl ester; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2021.113692

Reference yield:

: 33630-99-8
3-amino-2-pyridone

: 175210-52-3
methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / water; acetone / 3 h / 0 - 25 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 24 h / 20 °C

With sodium hydride; sodium carbonate; In tetrahydrofuran; water; acetone; 1.1: |Schotten-Baumann Reaction;
DOI:10.1016/j.ejmech.2021.113692

Reference yield:

: 6332-56-5
3-nitropyridone

: 175210-52-3
methyl (2S)-2-(3-{[(benzyloxy)carbonyl]amino}-2-oxo-1,2-dihydropyridin-1-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide; methanol / 21 h / 20 °C

2.1: sodium carbonate / water; acetone / 3 h / 0 - 25 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 24 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; sodium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; 2.1: |Schotten-Baumann Reaction;
DOI:10.1016/j.ejmech.2021.113692