3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

Base Information

Chemical Name:3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole
CAS No.:329076-33-7
Molecular Formula:C₂₀H₁₇FN₂O₃S
Molecular Weight:384.431
Hs Code.:

Synonyms:3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

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Chemical Property of 3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

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Technology Process of 3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

There total 14 articles about 3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 816-40-0
1-Bromo-2-butanone

: 329076-33-7
3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

Guidance literature:

Reference yield:

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 329076-33-7
3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

3: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

4: K₂CO₃ / dimethylformamide / 50 °C

5: 100 mg / p-TsOH*H₂O; CH₃CO₂H / toluene / Heating

With peracetic acid; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo049264k

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 329076-33-7
3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / H₂SO₄ / 8 h / Heating

2: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

3: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

4: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

5: K₂CO₃ / dimethylformamide / 50 °C

6: 100 mg / p-TsOH*H₂O; CH₃CO₂H / toluene / Heating

With peracetic acid; sulfuric acid; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo049264k