7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine
• CAS No.: 128615-93-0
• Molecular Formula: C₁₆H₁₃N₃O₂
• Molecular Weight: 279.298
• Mol file: 128615-93-0.mol

Synonyms:7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine

Chemical Property of 7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine

There total 1 articles about 7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-4-methylpyridine (695-34-1) + 4-nitrobenzaldehdye (555-16-8) + 1-chloro-3-(triphenylphosphoranylidene)acetone (13605-66-8) → 7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine (128615-93-0)

Guidance literature:

Yield given. Multistep reaction; 1.) dioxane, reflux, 2 h, 2.) iso-PrOH, reflux, 2 h;

DOI:10.1248/cpb.40.1818

Reference yield: 96.0%

7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine (128615-93-0) → 2-[2-(4-aminophenyl)ethyl]-7-methylimidazo[1,2-a]pyridine (128616-29-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; at 40 - 60 ℃; under 760 Torr;

DOI:10.1248/cpb.40.1818

upstream raw materials:

2-Amino-4-methylpyridine

4-nitrobenzaldehdye

1-chloro-3-(triphenylphosphoranylidene)acetone

Downstream raw materials:

2-[2-(4-aminophenyl)ethyl]-7-methylimidazo[1,2-a]pyridine