13605-66-8

Basic information

• Product Name: 3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE
• Synonyms: 3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE;3-Chloro-2-oxopropylidene triphenylphosphorane, 98 %;1-Chloro-3-(triphenylphosphoranylidene)acetone
• CAS NO: 13605-66-8
• Molecular Formula: C₂₁H₁₈ClOP
• Molecular Weight: 352.79
• Mol File: 13605-66-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 503.5 °C at 760 mmHg
• Flash Point: 258.3 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 2.88E-10mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE(13605-66-8)
• EPA Substance Registry System: 3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE(13605-66-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 13605-66-8(Hazardous Substances Data)

Usage

General Description

3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE is a chemical compound with the molecular formula C18H15ClO2P. It has a yellow to brown color and is typically used as a reagent in organic synthesis. 3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE is known for its ability to react with various organic compounds to form phosphoranes, which are important intermediates in the synthesis of organic compounds. It is also used in the preparation of phosphorus ylides, which are commonly used in the Wittig reaction to synthesize alkenes. Additionally, this compound has been studied for its potential applications in medicinal chemistry and drug discovery. Overall, 3-CHLORO-2-OXOPROPYLIDENE TRIPHENYLPHOSPHORANE is a versatile compound with important applications in organic synthesis and pharmaceutical research.

InChI:InChI=1/C21H18ClOP/c22-16-18(23)17-24(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17H,16H2

Upstream product

• 534-07-6 1,3-Dichloroacetone 
• 603-35-0 triphenylphosphine 
• 13605-65-7 (3-chloro-2-oxopropyl)triphenylphosphonium chloride 

Downstream Products

• 13605-49-7 Chlormethyl-<2-(4-nitro-phenyl)-vinyl>-keton 
• 13605-50-0 4-Acetamino-styryl-chlor-methyl-keton; 1-Chlor-4--but-3-en-2-on 
• 101454-29-9 3-(piperidin-1-yl)-1-triphenylphosphoranylidenepropan-2-one 
• 128615-93-0 7-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-imidazo[1,2-a]pyridine 
• 113727-88-1 1-<2-Oxo-3-(triphenylphosphoranylidene)propyl>-2,5-pyrrolidindion 
• 61955-82-6 2-Oxo-3-(phenylthio)propylidene triphenylphosphorane 
• 805315-71-3 3-(indolin-1-yl)-1-triphenylphosphoranylidenepropan-2-one 
• 1206881-21-1 (E)-1-chloro-4-(1-(4-nitrophenylsulfonyl)-1H-indol-3-yl)but-3-en-2-one 
• 1021603-72-4 C₃₃H₃₃O₃P 
• 249744-04-5 3-(2-oxo-3-triphenylphosphoranediylpropyl)-4(3H)-quinazolinone 
• 1009362-99-5 (E)-1-chloro-5-phenyl-3-hexen-2-one 
• 88981-42-4 (3E)-1-chloro-4-phenyl-3-buten-2-one 

Relevant articles and documents

High catalytic activity of a new Ag phosphorus ylide complex supported on montmorillonite: synthesis, characterization, and application for room temperature nitro reduction

In this work, the phosphorus ylide, [PPh3CHC(O)CH2Cl], was reacted with AgNO3 to give the [Ag{C(H)PPh3C(O)CH2Cl}2]+NO3? as the product. Then, it was supported on the modified montmorillonite nanoclay to prepare a new catalyst for the reduction reaction. The structure and morphology of the nanoclay catalyst were characterized by FT-IR, X-ray powder diffraction, scanning electron microscopy, energy-dispersive X-ray analysis and transmission electron microscopy techniques; also, the content of silver was obtained by inductively coupled plasma analyzer. This composition was exploited to study its catalytic activity in the reduction in aromatic nitro compounds; it displayed the high catalytic activity. Factors such as catalyst amount, solvent, temperature and reaction time were all systematically investigated to elucidate their effects on the yield of catalytic reduction in nitroarenes. This catalytic system exhibited high activity toward aromatic nitro compounds under mild conditions. The catalyst was reused five times without any significant loss in its catalytic activity.

FLUORESCENT SYSTEMS FOR BIOLOGICAL IMAGING AND USES THEREOF

The invention relates to compounds of formula I, in which Y, Ar1, Ar2, X, R1 and R2 are defined herein, and to their use in a variety of biological imaging techniques and therapeutic methods. In aspects, the invention relates to conjugates comprising the compounds of formula I and their associated uses and therapeutic uses.

AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.