trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt

Base Information

Chemical Name:trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt
CAS No.:858971-61-6
Molecular Formula:C₁₀H₁₆O₄S*C₁₅H₂₇NO₄
Molecular Weight:517.684
Hs Code.:

Synonyms:trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt

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Chemical Property of trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt

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Technology Process of trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt

There total 2 articles about trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 4-(N-t-butoxycarbonyl-(4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid

: 64-17-5
ethanol

: 35963-20-3,61380-66-3
(R)-10-camphorsulfonic acid

: 858971-61-6
trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt

Guidance literature:: 4-(N-t-butoxycarbonyl-(4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid; ethanol; With hydrogenchloride; at 50 ℃;

With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 1h;

(R)-10-camphorsulfonic acid; In 4-methyl-2-pentanone; Product distribution / selectivity;

Reference yield: 62.3%

: 4-(N-t-butoxycarbonyl-(4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid cyclohexylamine salt

: 64-17-5
ethanol

: 35963-20-3,61380-66-3
(R)-10-camphorsulfonic acid

: 858971-61-6
trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt

Guidance literature:: 4-(N-t-butoxycarbonyl-(4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid cyclohexylamine salt; With hydrogenchloride; In water; toluene;

ethanol; (R)-10-camphorsulfonic acid; at 70 ℃; for 5h; Product distribution / selectivity;

Reference yield: 94.3%

: 441715-25-9
[2,5-dichloro-4-(1-methyl-3-indolylcarbonylamino)phenyl]acetic acid

: 858971-61-6
trans-4-((4S)-methoxy-(2S)-pyrrolidinylmethoxy)cyclohexanecarboxylic acid ethyl ester (-)-camphorsulfonic acid salt

: 793669-62-2
trans-4-((2S,4S)-1-{2,5-dichloro-4-[(1-methylindol-3-yl)carboxamido]phenyl}acetyl-4-methoxypyrrolidin-2-yl)methoxycyclohexane-1-carboxylic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 5h; Product distribution / selectivity;