(R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide

Base Information

Chemical Name:(R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide
CAS No.:1290053-53-0
Molecular Formula:C₂₁H₂₃N₃O₅
Molecular Weight:397.431
Hs Code.:

Synonyms:(R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide

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Technology Process of (R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide

There total 9 articles about (R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.2%

: 1290056-36-8
(R)-tert-butyl 4-(4-(2-(3-(tert-butyldimethylsilyloxy)-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzylcarbamoyl)benzylcarbamate

: 1290053-53-0
(R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 767-00-0
4-cyanophenol

: 1290053-53-0
(R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 12 h / Reflux

2.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

3.2: 0.33 h / 0 - 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 20 °C

4.2: 0 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C

5.2: 16 h / 0 - 20 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

6.2: 0.58 h / -70 - 20 °C

7.1: hydrogenchloride / dichloromethane; diethyl ether / 4 h / 0 - 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; HATU; 10% palladium on charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 30041-95-3
ethyl (4-cyano-phenoxy)-acetate

: 1290053-53-0
(R)-4-(aminomethyl)-N-(4-(2-(3-hydroxy-4-oxopyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 0.33 h / 0 - 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 0 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C

4.2: 16 h / 0 - 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

5.2: 0.58 h / -70 - 20 °C

6.1: hydrogenchloride / dichloromethane; diethyl ether / 4 h / 0 - 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; HATU; 10% palladium on charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;