N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ⁵-benzoxazaphosphol-2-yl>serin methyl ester

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ⁵-benzoxazaphosphol-2-yl>serin methyl ester
• CAS No.: 156662-01-0
• Molecular Formula: C₁₉H₁₉Cl₂N₂O₉PS
• Molecular Weight: 553.314

Synonyms:N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ⁵-benzoxazaphosphol-2-yl>serin methyl ester

Chemical Property of N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ⁵-benzoxazaphosphol-2-yl>serin methyl ester

Chemical Property:

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Safty Information:

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Technology Process of N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ⁵-benzoxazaphosphol-2-yl>serin methyl ester

There total 6 articles about N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ⁵-benzoxazaphosphol-2-yl>serin methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-benzyloxycarbonyl-L-serine methyl ester (1676-81-9) + 2,5,7-trichloro-2,3-dihydro-3-(methylsulfonyl)-1,3,2-benzoxazaphosphole 2-oxide (156661-82-4) → N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ5-benzoxazaphosphol-2-yl>serin methyl ester (156662-01-0)

Guidance literature:

With triethylamine; In benzene; at 0 ℃; for 0.333333h;

Reference yield:

2,4-dichloro-6-nitrophenol (609-89-2) → N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ5-benzoxazaphosphol-2-yl>serin methyl ester (156662-01-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / H₂ / PtO₂ / ethanol / 96 h / 20 °C / 750.06 Torr

2: Et₃N / CH₂Cl₂ / 12 h / 20 °C

3: 69 percent / 10percent NaOH / H₂O / 12 h / 65 °C

4: Et₃N / diethyl ether; benzene / 20 h / 20 °C

5: PCl₅ / benzene; CH₂Cl₂ / 12 h / 20 °C

6: 90 percent / Et₃N / benzene / 0.33 h / 0 °C

With sodium hydroxide; phosphorus pentachloride; hydrogen; triethylamine; platinum(IV) oxide; In diethyl ether; ethanol; dichloromethane; water; benzene;

Reference yield:

2,4-dichloro-6-aminophenol (527-62-8) → N-(benzyloxycarbonyl)-O-<5,7-dichloro-2,3-dihydro-3-(methylsulfonyl)-2-oxo-1,3,2λ5-benzoxazaphosphol-2-yl>serin methyl ester (156662-01-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 69 percent / 10percent NaOH / H₂O / 12 h / 65 °C

3: Et₃N / diethyl ether; benzene / 20 h / 20 °C

4: PCl₅ / benzene; CH₂Cl₂ / 12 h / 20 °C

5: 90 percent / Et₃N / benzene / 0.33 h / 0 °C

With sodium hydroxide; phosphorus pentachloride; triethylamine; In diethyl ether; dichloromethane; water; benzene;

upstream raw materials:

N-benzyloxycarbonyl-L-serine methyl ester

2,5,7-trichloro-2,3-dihydro-3-(methylsulfonyl)-1,3,2-benzoxazaphosphole 2-oxide

2,4-dichloro-6-aminophenol

2,4-dichloro-6-nitrophenol

Downstream raw materials:

N-(benzyloxycarbonyl)-O-<<2,4-dichloro-6-<(methylsulfonyl)amino>phenoxy>ethoxyphosphoryl>serin methyl ester

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