609-89-2 Usage
Description
2,4-Dichloro-6-nitrophenol, also known as 2,4-DC6NP, is a chemical compound characterized by its yellow to orange powder form. It is a specific inhibitor of sulfotransferases, which are enzymes that catalyze the transfer of a sulfuryl group (sulfo group) to various acceptor molecules.
Uses
Used in Pharmaceutical Research:
2,4-Dichloro-6-nitrophenol is used as a research chemical for studying the inhibition of sulfotransferases. Its application in this field is crucial for understanding the role of these enzymes in various biological processes and their potential as therapeutic targets.
Used in Steroid Synthesis Inhibition:
In the field of endocrinology and biochemistry, 2,4-Dichloro-6-nitrophenol is used as an inhibitor to reduce the neosynthesis of [3H] pregnenolone sulfate (Δ5PS) and [3H]dehydroepiandrosterone sulfate (DHEAS). This application aids in the study of steroid hormone synthesis and its regulation, which is essential for understanding various physiological and pathological conditions related to steroid metabolism.
Used in Spectroscopic Studies:
The chemical properties of 2,4-Dichloro-6-nitrophenol, including its FT-Raman and FTIR spectra, are of interest to researchers in the field of spectroscopy. These studies can provide valuable insights into the molecular structure and interactions of 2,4-DC6NP, which can be useful for its further development and application in various scientific and industrial contexts.
Purification Methods
Crystallise the chloronitrophenol from AcOH. [Beilstein 6 IV 1358.]
Check Digit Verification of cas no
The CAS Registry Mumber 609-89-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 609-89:
(5*6)+(4*0)+(3*9)+(2*8)+(1*9)=82
82 % 10 = 2
So 609-89-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Cl2NO3/c7-3-1-4(8)6(10)5(2-3)9(11)12/h1-2,10H/p-1
609-89-2Relevant articles and documents
Preparation method of pentachloride intermediate 2, 4 - dichloro -6 - nitrophenol (by machine translation)
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Paragraph 0042; 0045-0049; 0050; 0052-0053; 0054; 0056-0057, (2019/08/06)
To the preparation method, 2, 4 - dichlorophenol sulfuric acid solution and nitric acid solution are respectively added to a continuous flow micro-channel reactor, and subjected to preheating, mixing, nitration reaction to obtain -6 - 2 dichloro 4 -6 - 4 - 2 -nitrophenol. The method comprises the following steps of: preheating, mixing and nitration reaction, and carrying out nitrification reaction. The method has the advantages of being convenient, safe, efficient, small in process environment pollution and the like, and can effectively avoid the generation. (by machine translation)
Room-Temperature, Water-Promoted, Radical-Coupling Reactions of Phenols with tert -Butyl Nitrite
Wei, Wen-Ting,Zhu, Wen-Ming,Liang, Weida,Wu, Yi,Huang, Hui-Yan,Huang, Yi-Ling,Luo, Junfei,Liang, Hongze
supporting information, p. 2153 - 2156 (2017/09/26)
A radical-radical cross-coupling reaction of phenols with tert -butyl nitrite has been developed with the use of water as an additive. This method allows the construction of C-N bonds under an air atmosphere at room temperature, providing the ortho -nitrated phenol derivative in moderate to good yields.
A new method for the mononitration of phenol derivatives by poly(4-vinylpyridinium nitrate) and silica sulfuric acid under mild conditions
Goudarziafshar, Hamid
experimental part, p. 458 - 461 (2012/06/18)
This procedure works efficiently for high selective mono nitration of phenol and substituted phenol to corresponding nitro compounds in moderate to high yield using poly(4-vinylpyridinium nitrate) and silica sulfuric acid in dichloromethane at room temperature.