Technology Process of (2R,5S)-2-benzyl-1-methyl-5-nonyl-3-oxopyrrolidine
There total 11 articles about (2R,5S)-2-benzyl-1-methyl-5-nonyl-3-oxopyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: toluene / 2 h / Heating
2: TFA / 2 h / Heating
3: H2, conc. aq. HCl / Pd/C / methanol / 12 h / 23 °C / 760 Torr
4: NaHCO3 / 1 h / 23 °C
5: urea-H2O2 complex, TFAA, 3-isobutyl-4-hydroxy-5-methylphenylsulfide / CH2Cl2 / 48 h / -4 °C
6: LiAlH4 / tetrahydrofuran / 7 h / 23 °C
7: (COCl2)2, DMSO / CH2Cl2 / 30 h / -55 - -40 °C
With
hydrogenchloride; lithium aluminium tetrahydride; 3-isobutyl-4-hydroxy-5-methylphenylsulfide; (COCl2)2; hydrogen; urea hydrogen peroxide adduct; sodium hydrogencarbonate; dimethyl sulfoxide; trifluoroacetic acid; trifluoroacetic anhydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ja00104a005
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 76 percent / tetrahydrofuran / 21 h / 25 °C
2: 1.) KH, 3.) aq. KOH
3: toluene / 2 h / Heating
4: TFA / 2 h / Heating
5: H2, conc. aq. HCl / Pd/C / methanol / 12 h / 23 °C / 760 Torr
6: NaHCO3 / 1 h / 23 °C
7: urea-H2O2 complex, TFAA, 3-isobutyl-4-hydroxy-5-methylphenylsulfide / CH2Cl2 / 48 h / -4 °C
8: LiAlH4 / tetrahydrofuran / 7 h / 23 °C
9: (COCl2)2, DMSO / CH2Cl2 / 30 h / -55 - -40 °C
With
hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; 3-isobutyl-4-hydroxy-5-methylphenylsulfide; (COCl2)2; hydrogen; urea hydrogen peroxide adduct; potassium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; trifluoroacetic acid; trifluoroacetic anhydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ja00104a005
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) KH, 3.) aq. KOH
2: toluene / 2 h / Heating
3: TFA / 2 h / Heating
4: H2, conc. aq. HCl / Pd/C / methanol / 12 h / 23 °C / 760 Torr
5: NaHCO3 / 1 h / 23 °C
6: urea-H2O2 complex, TFAA, 3-isobutyl-4-hydroxy-5-methylphenylsulfide / CH2Cl2 / 48 h / -4 °C
7: LiAlH4 / tetrahydrofuran / 7 h / 23 °C
8: (COCl2)2, DMSO / CH2Cl2 / 30 h / -55 - -40 °C
With
hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; 3-isobutyl-4-hydroxy-5-methylphenylsulfide; (COCl2)2; hydrogen; urea hydrogen peroxide adduct; potassium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; trifluoroacetic acid; trifluoroacetic anhydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ja00104a005
