(2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane

Base Information

Chemical Name:(2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane
CAS No.:147426-12-8
Molecular Formula:C₂₃H₃₇NO₃
Molecular Weight:375.552
Hs Code.:

Synonyms:(2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane

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Technology Process of (2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane

There total 4 articles about (2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7782-24-3
(S)-2-Phenylpropionic acid

: 147426-12-8
(2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 90 deg C, 2 h, then room temp., overnight

2: pyridine / 1.) below 4 deg C, 0.5 h 2.) refrigerator, overnight

3: LiBr / acetone / 18 h / Heating

4: 1.) Mg, 1,2-dibromoethane / 1.) THF, 40 - 50 deg C, 30 min 2.) THF, room temp., 30 min

With pyridine; magnesium; ethylene dibromide; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium bromide; In acetone; toluene;
DOI:10.1021/jo00060a052

Reference yield:

: 37778-99-7
(S)-2-phenyl-1-propanol

: 147426-12-8
(2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1.) below 4 deg C, 0.5 h 2.) refrigerator, overnight

2: LiBr / acetone / 18 h / Heating

3: 1.) Mg, 1,2-dibromoethane / 1.) THF, 40 - 50 deg C, 30 min 2.) THF, room temp., 30 min

With pyridine; magnesium; ethylene dibromide; lithium bromide; In acetone;
DOI:10.1021/jo00060a052

Reference yield:

: 74669-73-1
2-phenylpropyl 4-methylbenzenesulfonate

: 147426-12-8
(2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-hydroxy-2-phenylhexane

Guidance literature:: Multi-step reaction with 2 steps

1: LiBr / acetone / 18 h / Heating

2: 1.) Mg, 1,2-dibromoethane / 1.) THF, 40 - 50 deg C, 30 min 2.) THF, room temp., 30 min

With magnesium; ethylene dibromide; lithium bromide; In acetone;
DOI:10.1021/jo00060a052