5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole
CAS No.:1067185-72-1
Molecular Formula:C₂₃H₂₈N₄O₅S
Molecular Weight:472.565
Hs Code.:

Synonyms:5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole

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Chemical Property of 5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole

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Technology Process of 5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole

There total 1 articles about 5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1067185-77-6
5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylthio)-1-phenyl-1H-tetrazole

: 1067185-72-1
5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 21h;
DOI:10.1016/j.tetlet.2008.07.022

Reference yield:

: 1067185-72-1
5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole

: 1067185-71-0
(4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxane-4-carbaldehyde

: 1067185-80-1
(2-((4S,6S)-6-(3-((4S,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)prop-1-enyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethoxy)(tert-butyl)diphenylsilane

: 1067185-79-8
(2-((4S,6S)-6-(3-((4S,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)prop-1-enyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethoxy)(tert-butyl)diphenylsilane

Guidance literature:: 5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole; (4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxane-4-carbaldehyde; With lithium hexamethyldisilazane; In 1,2-dimethoxyethane; hexane; at -78 ℃; for 20h;

With 18-crown-6 ether; lithium hexamethyldisilazane; In 1,2-dimethoxyethane; hexane; at 20 ℃; for 18h; Further stages. Title compound not separated from byproducts.;
DOI:10.1016/j.tetlet.2008.07.022