11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Base Information

Chemical Name:11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester
CAS No.:1290538-45-2
Molecular Formula:C₃₅H₅₇N₇O₆
Molecular Weight:671.881
Hs Code.:

Synonyms:11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

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Chemical Property of 11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

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Technology Process of 11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

There total 6 articles about 11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1290538-44-1
11-(2-azidoethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

: 536-74-3
phenylacetylene

: 1290538-45-2
11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: With copper(II) sulfate penta hydrate; sodium L-ascorbate; In tetrahydrofuran; water; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejic.201601474

Reference yield:

: 170161-27-0
1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 1290538-45-2
11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 72 h / Reflux

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 16 h / 20 °C

With copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/chem.201002477

Reference yield:

: 295-37-4
1,4,8,11-Tetraazacyclotetradecane

: 1290538-45-2
11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16.25 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 72 h / Reflux

3: copper(II) sulfate penta hydrate; sodium L-ascorbate / water; tetrahydrofuran / 16 h / 50 °C / Inert atmosphere

With copper(II) sulfate penta hydrate; potassium carbonate; sodium L-ascorbate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/ejic.201601474