1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane

Base Information

Chemical Name:1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane
CAS No.:1290538-46-3
Molecular Formula:C₂₀H₃₃N₇
Molecular Weight:371.529
Hs Code.:

Synonyms:1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane

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Chemical Property of 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane

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Technology Process of 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane

There total 6 articles about 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1290538-45-2
11-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

: 1290538-46-3
1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1002/chem.201002477

Reference yield:

: 170161-27-0
1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 1290538-46-3
1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / acetonitrile / 72 h / Reflux

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 16 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; trifluoroacetic acid; In dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/chem.201002477

Reference yield:

: 295-37-4
1,4,8,11-Tetraazacyclotetradecane

: 1290538-46-3
1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 16.25 h / 0 - 20 °C

2.1: potassium carbonate / acetonitrile / 72 h / Reflux

3.1: copper(II) sulfate penta hydrate; sodium L-ascorbate / water; tetrahydrofuran / 16 h / 50 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

4.2: Ambersep^? 900 resin / 20 °C

With hydrogenchloride; copper(II) sulfate penta hydrate; potassium carbonate; sodium L-ascorbate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1002/ejic.201601474