ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate

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Chemical Name:ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate
CAS No.:1609930-25-7
Molecular Formula:C₁₉H₁₆BrF₃N₂O₃
Molecular Weight:457.247
Hs Code.:

Synonyms:ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate

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Chemical Property of ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate

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Technology Process of ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate

There total 7 articles about ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1409953-33-8
ethyl 5-bromo-3-(2,2,2-trifluoroacetyl)-1H-indol-2-ylcarbamate

: 1609930-25-7
ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate

Guidance literature:: In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1039/c3ob42186d

Reference yield:

: 956903-53-0
methyl 2-(4-bromophenylhydrazono)propionate

: 1609930-25-7
ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; water / 2.5 h / Reflux; Inert atmosphere; Acidic conditions

2: hydrazine hydrate / ethanol / 5 h / Reflux

3: acetic acid; sodium nitrite / water; 1,4-dioxane / 0 °C

4: Reflux

5: 0 °C

6: tetrahydrofuran / 0 °C / Inert atmosphere

With hydrazine hydrate; acetic acid; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 1: |Fischer Indole Synthesis / 4: |Curtius Rearrangement;
DOI:10.1039/c3ob42186d

Reference yield:

: 20948-71-4
5-bromo-indole-2-carbohydrazide

: 1609930-25-7
ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium nitrite / water; 1,4-dioxane / 0 °C

2: Reflux

3: 0 °C

4: tetrahydrofuran / 0 °C / Inert atmosphere

With acetic acid; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; water; 2: |Curtius Rearrangement;
DOI:10.1039/c3ob42186d