(2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

Base Information

Chemical Name:(2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate
CAS No.:1353676-03-5
Molecular Formula:C₂₁H₁₇ClO₄
Molecular Weight:368.817
Hs Code.:

Synonyms:(2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

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Chemical Property of (2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

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Technology Process of (2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

There total 2 articles about (2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 90-15-3
α-naphthol

: 105213-30-7
4-(2-chlorophenyl)-2-oxo-3-butenoic acid methyl ester

: 1353676-03-5
(2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

Guidance literature:: 4-(2-chlorophenyl)-2-oxo-3-butenoic acid methyl ester; With 1-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea; In diethyl ether; at 25 ℃; for 0.5h; Inert atmosphere;

α-naphthol; In diethyl ether; at 25 ℃; for 36h; stereoselective reaction; Inert atmosphere;
DOI:10.1039/c1cc14379d

Reference yield:

: 90-15-3
α-naphthol

: 105213-30-7
4-(2-chlorophenyl)-2-oxo-3-butenoic acid methyl ester

: 1353676-18-2
(2S,4S)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

: 1353676-03-5
(2R,4R)-methyl 4-(2-chlorophenyl)-2-hydroxy-3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

Guidance literature:: 4-(2-chlorophenyl)-2-oxo-3-butenoic acid methyl ester; With 1-((1S,2S)-2-(dimethylamino)cyclohexyl)-3-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)thiourea; In diethyl ether; at 25 ℃; for 0.5h; Inert atmosphere;

α-naphthol; In diethyl ether; at 25 ℃; for 36h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;
DOI:10.1039/c1cc14379d