10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine

Base Information

Chemical Name:10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine
CAS No.:1416850-64-0
Molecular Formula:C₂₇H₁₉N₃OS₂
Molecular Weight:465.599
Hs Code.:

Synonyms:10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine

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Chemical Property of 10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine

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Technology Process of 10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine

There total 2 articles about 10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 92-84-2
10H-phenothiazine

: 1416850-52-6
5-(4-bromophenyl)-4-methoxy-2-(pyridin-2-yl)thiazole

: 1416850-64-0
10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine

Guidance literature:: 10H-phenothiazine; 5-(4-bromophenyl)-4-methoxy-2-(pyridin-2-yl)thiazole; With potassium tert-butylate; In toluene; for 0.5h; Inert atmosphere;

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; Reflux; Inert atmosphere;
DOI:10.1002/ejoc.201200688

Reference yield:

: 1233941-59-7
5-(4-bromophenyl)-2-(pyridin-2-yl)-1,3-thiazol-4-ol

: 1416850-64-0
10-{4-[4-methoxy-2-(pyridin-2-yl)thiazol-5-yl]phenyl}-10H-phenothiazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

1.2: 24 h / 20 °C

2.1: potassium tert-butylate / toluene / 0.5 h / Inert atmosphere

2.2: Reflux; Inert atmosphere

With potassium tert-butylate; potassium hydroxide; In dimethyl sulfoxide; toluene; 2.1: |Buchwald-Hartwig Coupling / 2.2: |Buchwald-Hartwig Coupling;
DOI:10.1002/ejoc.201200688