2-(2-{(R)-4-[6-(2,4-Difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidin-5-yl)-propan-2-ol

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Chemical Name:2-(2-{(R)-4-[6-(2,4-Difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidin-5-yl)-propan-2-ol
CAS No.:1204975-10-9
Molecular Formula:C₂₆H₂₉F₅N₆O
Molecular Weight:536.548
Hs Code.:

Synonyms:2-(2-{(R)-4-[6-(2,4-Difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidin-5-yl)-propan-2-ol

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Chemical Property of 2-(2-{(R)-4-[6-(2,4-Difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidin-5-yl)-propan-2-ol

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Technology Process of 2-(2-{(R)-4-[6-(2,4-Difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidin-5-yl)-propan-2-ol

There total 1 articles about 2-(2-{(R)-4-[6-(2,4-Difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidin-5-yl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1204975-08-5
2-{(R)-4-[6-(2,4-difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester

: 75-16-1
methylmagnesium bromide

: 1204975-10-9
2-(2-{(R)-4-[6-(2,4-Difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidin-5-yl)-propan-2-ol

Guidance literature:: 2-{(R)-4-[6-(2,4-difluoro-benzyl)-4,5-dimethyl-pyridazin-3-yl]-2-methyl-piperazin-1-yl}-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h; Cooling with ice;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;