methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

Base Information

Chemical Name:methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate
CAS No.:1360821-08-4
Molecular Formula:C₃₁H₃₂ClFN₄O₅
Molecular Weight:595.07
Hs Code.:

methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

Synonyms:methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

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Chemical Property of methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

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Technology Process of methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

There total 4 articles about methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl racemic 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

: 1360821-07-3
methyl 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

: 1360821-08-4
methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

Guidance literature:: With Waters/Thar Multi-Gram II, Kromasil 5-CelluCoat OD 3*25 cm; In methanol; carbon dioxide; at 35 ℃; under 75007.5 Torr; Purification / work up; Resolution of racemate;

Reference yield:

: 134682-54-5
5-azaindolin-2-one

: 1360821-07-3
methyl 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

: 1360821-08-4
methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / methanol / 50 °C

2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

2.2: 23 h / 40 °C

3.1: Waters/Thar Multi-Gram II, Kromasil 5-CelluCoat OD 3*25 cm / methanol; carbon dioxide / 35 °C / 75007.5 Torr / Resolution of racemate

With piperidine; lithium hydroxide; In tetrahydrofuran; methanol; carbon dioxide;

Reference yield:

: 1360821-89-1
E/Z-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydropyrrolo[3,2-c]pyridin-2-one

: 1360821-07-3
methyl 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

: 1360821-08-4
methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

1.2: 23 h / 40 °C

2.1: Waters/Thar Multi-Gram II, Kromasil 5-CelluCoat OD 3*25 cm / methanol; carbon dioxide / 35 °C / 75007.5 Torr / Resolution of racemate

With lithium hydroxide; In tetrahydrofuran; methanol; carbon dioxide;