134682-54-5

Basic information

• Product Name: 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI)
• Synonyms: 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI);1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE;5-Azaoxindole;1,3-Dihydro-2H-pyrrolo[3,2-c]pyridin-2-one;1,3-Dihydro-2H-pyrrolo[3,...;5-Aza-2-oxindole;1,3-dihydro-pyrolo[3,2-C]pyridin-2-one;1,3-DIHYDRO-2H-PYRROLO(3,2-C)PYRIDN-2-ONE
• CAS NO: 134682-54-5
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• EINECS: 200-258-5
• Product Categories: PYRIDINE
• Mol File: 134682-54-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 362.5 °C at 760 mmHg
• Flash Point: 173 °C
• Appearance: /
• Density: 1.286
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.58±0.20(Predicted)
• CAS DataBase Reference: 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI)(134682-54-5)
• EPA Substance Registry System: 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI)(134682-54-5)

Safety Data

• Hazardous Substances Data: 134682-54-5(Hazardous Substances Data)

Usage

General Description

"2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI)" is a chemical compound with a specific molecular structure, belonging to the class of organic compounds known as Pyrrolopyridines. Pyrrolopyridines are compounds containing a Pyrrolopyridine moiety, which consists of a pyrrole ring fused to a pyridine ring. It is a heterocyclic compound, meaning it contains atoms of at least two different elements in its rings. The chemical does not have well-documented applications or notable physical and chemical properties in commonly accessible resources, indicating it might not have any widespread industrial use, or it is primarily used in scientific research.

Upstream product

• 134682-56-7 C₇H₄Br₂N₂O 
• 123367-22-6 (E)-N,N-dimethyl-2-(4-nitro-1-oxidopyridin-3-yl)ethenamine 
• 108-99-6 3-Methylpyridine 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1003-73-2 3-picoline-N-oxide 
• 271-34-1 5-azaindole 
• 134682-57-8 3,3,7-tribromo-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one 

Downstream Products

• 1637481-10-7 C₁₅H₈ClN₃O₂ 
• 1360821-89-1 E/Z-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydropyrrolo[3,2-c]pyridin-2-one 
• 1360821-07-3 methyl 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate 
• 1360821-08-4 methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate 
• 1360821-09-5 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid 
• 1360821-10-8 rac-(2S,3R,4S,5R)-N-(4-carbamoyl-2-methoxyphenyl)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide 

Relevant articles and documents

Synthesis of 5-Azaoxindole

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Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents

Three series of 3-substituted-indolin-2-ones and azaindolin-2-ones have been synthesized and showed potential antiproliferative activity to cancer cell lines. The inhibition activities on VEGF-induced VEGFR phosphorylation were observed for selected 2-indolinones. Among the compounds synthesized, 5-fluoroindolin-2-one derivative 23 with a pyridone unit showed the most significant enzymatic and cellular activities. Flow cytometric analysis indicates that 23 plays a role in suppressing HCT-116 cell proliferation via G1 phase arrest and apoptosis in a dose dependent manner. The binding mode of compound 23 complexed with VEGFR-2 was predicted using FlexX algorithm. Described here are the chemistry and biological testing for these series which will guide the design and optimization of novel 2-indolione antitumor agents.