134682-54-5

Usage

Uses

Since the provided materials do not specify any particular applications for 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI), it is not possible to list its uses in different industries or as an application type for a specific reason. However, given its classification as a Pyrrolopyridine, it may be involved in various research and development activities, such as the synthesis of new compounds, pharmaceuticals, or materials science applications. Further research and documentation would be required to determine its specific uses and applications.

Upstream product

• 123367-22-6 (E)-N,N-dimethyl-2-(4-nitro-1-oxidopyridin-3-yl)ethenamine 
• 108-99-6 3-Methylpyridine 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1003-73-2 3-picoline-N-oxide 
• 134682-56-7 C₇H₄Br₂N₂O 
• 271-34-1 5-azaindole 
• 134682-57-8 3,3,7-tribromo-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one 

Downstream Products

• 1637481-10-7 C₁₅H₈ClN₃O₂ 
• 1360821-89-1 E/Z-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydropyrrolo[3,2-c]pyridin-2-one 
• 1360821-07-3 methyl 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate 
• 1360821-08-4 methyl 4-((2R,3S,4R,5S)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate 
• 1360821-09-5 4-((2S,3R,4S,5R)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid 
• 1360821-10-8 rac-(2S,3R,4S,5R)-N-(4-carbamoyl-2-methoxyphenyl)-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide 

Relevant academic research and scientific papers

Design, synthesis and antiproliferative activity evaluation of new 5-azaisoindigo derivatives

New 5-azaisoindigo derivatives were synthesized with two key intermediates 5-azaoxindole (7) and substituted indole-2,3-dione (10) in this paper. Intermediate 7 was prepared from 3-methylpyridine (1) through 6 steps containing oxidation reaction and so on. Intermediate 10 was obtained by a convenient Sandmeyer's method. The target compounds 5-azaisoindigo derivatives 11a-f were obtained by condensation of these two intermediates 7 and 10 in acidic condition. All target compounds were evaluated for their antiproliferative activity against seven cell lines by SRB assay. Compounds 11e and 11f showed significant antiproliferative activity against K562 cells (IC50: 8.9 μM and 13.6 μM, respectively).

Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents

Three series of 3-substituted-indolin-2-ones and azaindolin-2-ones have been synthesized and showed potential antiproliferative activity to cancer cell lines. The inhibition activities on VEGF-induced VEGFR phosphorylation were observed for selected 2-indolinones. Among the compounds synthesized, 5-fluoroindolin-2-one derivative 23 with a pyridone unit showed the most significant enzymatic and cellular activities. Flow cytometric analysis indicates that 23 plays a role in suppressing HCT-116 cell proliferation via G1 phase arrest and apoptosis in a dose dependent manner. The binding mode of compound 23 complexed with VEGFR-2 was predicted using FlexX algorithm. Described here are the chemistry and biological testing for these series which will guide the design and optimization of novel 2-indolione antitumor agents.