(2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride

Base Information

Chemical Name:(2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride
CAS No.:132154-76-8
Molecular Formula:C₁₉H₃₈N₂O₂*ClH
Molecular Weight:362.984
Hs Code.:

Synonyms:(2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride

Chemical Property:

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Technology Process of (2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride

There total 1 articles about (2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 5-[2-[(Butylamino)carbonyl]-3-methylbutyl]-4-(cyclohexylmethyl)-2,2-dimethyl-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester

: 132154-76-8
(2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride

Guidance literature:: In 1,4-dioxane; hydrogenchloride; methanol;

Reference yield:

: 1336-21-6
ammonium hydroxide

CH₂ Cl₂:MeOH: CH₂ Cl₂:MeOH

: 1119-16-0
isocaproic aldehyde

: 132154-76-8
(2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride

: 192386-60-0
[αS-(αR*,γR*,δR*)]N-Butyl-γ-hydroxy-α-(1-methylethyl)-δ-[(4-methylpentyl)amino]cyclohexanehexanamide hydrochloride

Guidance literature:: With hydrogenchloride; sodium acetate; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; In methanol; ethanol; water;

Reference yield:

: 132154-76-8
(2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane hydrochloride

: 140660-69-1
(2S,4S)-3-aza-2-butyl-4-<<4-(1,3-dioxabutyl)piperidin-1-yl>carbonyl>-5-phenylpentanoic acid

: 140676-35-3
(2S,4S)-3-aza-2-butyl-4-<<4-(1,3-dioxabutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3S,5S)-2-amino-1-cyclohexyl-3-hydroxy-5-(n-butylcarbamoyl)-6-methylheptane

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Yield given. Multistep reaction; 1.) DMF, -23 deg C, 2.) DMF, from -23 deg C to RT, 18 h;
DOI:10.1021/jm00088a006