(4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

Base Information

Chemical Name:(4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane
CAS No.:220936-37-8
Molecular Formula:C₂₂H₃₆O₅
Molecular Weight:380.525
Hs Code.:

Synonyms:(4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

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Chemical Property of (4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

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Technology Process of (4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

There total 1 articles about (4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (4R,5R)-(-)-4,5-bis(3-hydroxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

: 74-88-4
methyl iodide

: 220936-37-8
(4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 18h; Heating;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<503::AID-EJOC503>3.0.CO;2-I

Reference yield: 71.0%

: 220936-37-8
(4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

: 220936-38-9
(-)-<(4R,5R)-3,6-diethyl-5-hydroxy-3,6-dimethoxyoctan-4-yl> 4-methoxybenzoate

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 1.5h; Ambient temperature;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<503::AID-EJOC503>3.0.CO;2-I

Reference yield:

: 220936-37-8
(4R,5R)-(-)-4,5-bis(3-methoxypentan-3-yl)-2-(4-methoxyphenyl)-1,3-dioxolane

: N-<(αR and αS)-2-<<(4R,5R)-4,5-bis(3-methoxypentan-3-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / DDQ / H₂O; CH₂Cl₂ / 1.5 h / Ambient temperature

2: 54 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 14 h / Heating

3: 51 percent / p-toluenesulfonic acid, molecular sieves 4 Angstroem / tetrahydrofuran / 72 h / Heating

4: 1.) n-butyllithium / 1.) hexane, THF, -100 deg C, 15 min, 2.) THF, -85 to -100 deg C, 6 h

With lithium aluminium tetrahydride; n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<503::AID-EJOC503>3.0.CO;2-I