5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid

Base Information

• Chemical Name: 5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid
• CAS No.: 101134-93-4
• Molecular Formula: C₂₅H₁₈N₄O₄
• Molecular Weight: 438.442
• Mol file: 101134-93-4.mol

Synonyms:5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid

Chemical Property of 5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid

There total 4 articles about 5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4-[(4-Benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carboxylic acid ethyl ester → 5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid (101134-93-4)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00398a017

Reference yield:

4-nitro-1H-indole-2-carboxylic acid ethyl ester (4993-93-5) → 5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid (101134-93-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / hydrogen / PtO₂ / ethanol; tetrahydrofuran / 3.25 h / 724.01 Torr

2: 81 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 48 h

3: 97 percent / aq. KOH / methanol; dimethylformamide / 0.5 h

4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 48 h

5: 51 percent / aq. KOH / dimethylformamide

With potassium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00398a017

Reference yield:

5-(benzylamino)-1H-indole-2-carboxylic acid (112089-66-4) → 5-<<<5-(benzoylamino)-1H-indol-2-yl>carbonyl>amino>-1H-indole-2-carboxylic acid (101134-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 48 h

2: 51 percent / aq. KOH / dimethylformamide

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00398a017

upstream raw materials:

4-nitro-1H-indole-2-carboxylic acid ethyl ester

5-(benzylamino)-1H-indole-2-carboxylic acid

ethyl 5-(benzylamino)-1H-indole-2-carboxylate

Downstream raw materials:

Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

C₃₇H₂₈N₆O₄

5-Benzoylamino-1H-indole-2-carboxylic acid [2-(5-benzyloxy-1-hydroxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl]-amide