tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate

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Chemical Name:tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate
CAS No.:120368-87-8
Molecular Formula:C₂₉H₄₄N₈O₉P₂
Molecular Weight:710.664
Hs Code.:

Synonyms:tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate

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Chemical Property of tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate

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Technology Process of tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate

There total 4 articles about tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 52853-40-4
6-bromomethyl-2,4-diaminopteridine hydrobromide

: 120355-34-2
tetraethyl 3-ethoxycarbonyl-N-<4-(methylamino)benzoyl>-3-aminopropylidene-1,1-bisphosphonate

: 120368-87-8
tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate

Guidance literature:: In N,N-dimethyl acetamide; at 50 ℃; for 4h;
DOI:10.1016/0223-5234(92)90117-J

Reference yield:

: 120355-30-8
2-amino-4,4-bis(diethylphosphono)butanoic acid ethyl ester

: 120368-87-8
tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

2: KH₂PO₄, Zn / H₂O; tetrahydrofuran / 24 h / Ambient temperature

3: 68 percent / N,N-dimethyl-acetamide / 4 h / 50 °C

With potassium dihydrogenphosphate; triethylamine; zinc; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1016/0223-5234(92)90117-J

Reference yield:

: (4-Chlorocarbonyl-phenyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

: 120368-87-8
tetraethyl N-(4-<(<2,4-diamino-6-pteridinyl>methyl) methyl-amino>benzoyl)-3-amino-3-ethoxycarbonylpropylidene-1,1-bisphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

2: KH₂PO₄, Zn / H₂O; tetrahydrofuran / 24 h / Ambient temperature

3: 68 percent / N,N-dimethyl-acetamide / 4 h / 50 °C

With potassium dihydrogenphosphate; triethylamine; zinc; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1016/0223-5234(92)90117-J