1-(bromomethyl)cyclohexanecarboxaldehyde

Base Information

• Chemical Name: 1-(bromomethyl)cyclohexanecarboxaldehyde
• CAS No.: 119005-36-6
• Molecular Formula: C₈H₁₃BrO
• Molecular Weight: 205.095
• Mol file: 119005-36-6.mol

Synonyms:1-(bromomethyl)cyclohexanecarboxaldehyde

Chemical Property of 1-(bromomethyl)cyclohexanecarboxaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of 1-(bromomethyl)cyclohexanecarboxaldehyde

There total 1 articles about 1-(bromomethyl)cyclohexanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1-bromomethyl-cyclohexyl)-methanol (72335-64-9) → 1-(bromomethyl)cyclohexanecarboxaldehyde (119005-36-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 7h;

DOI:10.1002/recl.19881070505

Reference yield: 68.0%

O-benzylhydoxylamine hydrochloride (2687-43-6) + 1-(bromomethyl)cyclohexanecarboxaldehyde (119005-36-6) → 1-(bromomethyl)cyclohexanecarboxaldehyde O-(phenylmethyl)oxime (119005-39-9)

Guidance literature:

With sodium hydroxide; In methanol; for 4h;

DOI:10.1002/recl.19881070505

Reference yield:

1-(bromomethyl)cyclohexanecarboxaldehyde (119005-36-6) → 2-(phenylmethoxy)-2-azaspiro<3.5>nonane (118975-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / NaOH / methanol / 4 h

2: 87 percent / NaCNBH₃ / acetic acid

3: 92 percent / pyridine / 6 h / 100 °C

With sodium hydroxide; sodium cyanoborohydride; In pyridine; methanol; acetic acid;

DOI:10.1002/recl.19881070505

upstream raw materials:

(1-bromomethyl-cyclohexyl)-methanol

Downstream raw materials:

1-(bromomethyl)cyclohexanecarboxaldehyde O-(phenylmethyl)oxime

2-(phenylmethoxy)-2-azaspiro<3.5>nonane

1-(bromomethyl)-N-(phenylmethoxy)cyclohexanemethanamine

Refernces