(3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Base Information

• Chemical Name: (3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate
• CAS No.: 912969-49-4
• Molecular Formula: C₂₁H₃₀N₂O₃
• Molecular Weight: 358.481
• Mol file: 912969-49-4.mol

Synonyms:(3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Chemical Property of (3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of (3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

There total 1 articles about (3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[1S,2(2E)]-2-(N-benzyl-N-(4-chlorobut-2-enyl)-amino)-1-tributylstannylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate → (3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate (912969-49-4)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 2h;

DOI:10.1021/ol061615p

Reference yield: 56.0%

(3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate (912969-49-4) → (3S,4R)-1-benzyl-4-vinylpyrrolidin-3-ol (912969-50-7)

Guidance literature:

(3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate; With methanol; methanesulfonic acid; for 3h; Heating;

With methanol; potassium carbonate; for 18h; Heating;

DOI:10.1021/ol061615p

Reference yield:

(3S,4R)-3-(1-benzyl-4-vinyl-pyrrolidin-3-yl) 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate (912969-49-4) → (3S,4R)-1-benzyl-4-vinylpyrrolidin-3-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanesulfonic acid; methanol / 3 h / Heating

1.2: 56 percent / K₂CO₃; methanol / 18 h / Heating

2.1: 47 percent / pyridine / CCl₄ / 20 °C

With pyridine; methanol; methanesulfonic acid; In tetrachloromethane;

DOI:10.1021/ol061615p

Downstream raw materials:

(3S,4R)-1-benzyl-4-vinylpyrrolidin-3-ol