(S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid

Base Information

Chemical Name:(S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid
CAS No.:1448621-49-5
Molecular Formula:C₁₆H₂₂ClNO₄Se
Molecular Weight:406.768
Hs Code.:

Synonyms:(S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid

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Chemical Property of (S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid

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Technology Process of (S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid

There total 7 articles about (S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1448621-35-9
(S)-tert-butyl 2-((2-chlorophenylselanyl)methyl)-5-oxopyrrolidine-1-carboxylate

: 1448621-49-5
(S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid

Guidance literature:: (S)-tert-butyl 2-((2-chlorophenylselanyl)methyl)-5-oxopyrrolidine-1-carboxylate; With lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water;
DOI:10.1039/c3ob40879e

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1448621-49-5
(S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 3 h / 0 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0.17 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran / 20 °C

With dmap; sodium tetrahydroborate; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1039/c3ob40879e

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 1448621-49-5
(S)-4-(tert-butoxycarbonylamino)-5-(2-chlorophenylselanyl)pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / 63 h / Reflux

2.1: thionyl chloride / 48 h / 20 °C

3.1: sodium tetrahydroborate; ethanol / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 3 h / 0 °C

5.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0.17 h / 20 °C / Inert atmosphere

5.2: 24 h / 20 °C / Inert atmosphere

6.1: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

7.1: lithium hydroxide / tetrahydrofuran / 20 °C

With dmap; sodium tetrahydroborate; thionyl chloride; ethanol; water; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1039/c3ob40879e