(S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide

Base Information

Chemical Name:(S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide
CAS No.:1380100-77-5
Molecular Formula:C₁₇H₂₃FN₂O
Molecular Weight:290.381
Hs Code.:

Synonyms:(S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide

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Chemical Property of (S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide

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Technology Process of (S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide

There total 3 articles about (S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 403-15-6
4-fluoro-3-methyl-benzoic acid

: 1380104-23-3
(S)-2-(azetidin-1-yl)-1-cyclopropyl-N-methylethanamine

: 1380100-77-5
(S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide

Guidance literature:: 4-fluoro-3-methyl-benzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

(S)-2-(azetidin-1-yl)-1-cyclopropyl-N-methylethanamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 155976-13-9
(2S)-2-[[(tert-butoxy)carbonyl]amino]-2-cyclopropylacetic acid

: 1380100-77-5
(S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 60 °C / Inert atmosphere

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

3.2: 6 h / 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1380103-95-6
(S)-tert-butyl 2-(azetidin-1-yl)-1-cyclopropyl-2-oxoethylcarbamate

: 1380100-77-5
(S)-N-(2-(azetidin-1-yl)-1-cyclopropylethyl)-4-fluoro-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 60 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

2.2: 6 h / 20 °C

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;