155976-13-9

Basic information

• Product Name: Boc-L-cyclopropylglycine
• Synonyms: (S)-TERT-BUTOXYCARBONYLAMINO-CYCLOPROPYL-ACETIC ACID;BOC-L-CYCLOPROPYLGLYCINE 98%;(S)-Amino(cyclopropyl)acetic acid, N-BOC protected;L-Cyclopropylglycine, N-BOC protected;N-tert-Butoxycarbonyl-L-cyclopropylglycine;Cyclopropaneacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, (.alpha.S)-;(2S)-[(tert-Butoxycarbonyl)amino](cyclopropyl)acetic acid;Boc-(S)-2-Cyclopropylglycine
• CAS NO: 155976-13-9
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.25
• Product Categories: Unusual amino acids;pharmacetical;Amino Acid Derivatives;a-amino
• Mol File: 155976-13-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 79 °C
• Boiling Point: 364.7 °C at 760 mmHg
• Flash Point: 174.4 °C
• Appearance: White/Powder
• Density: 1.206 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: 2-8°C
• PKA: 3.97±0.10(Predicted)
• BRN: 6650020
• CAS DataBase Reference: Boc-L-cyclopropylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-cyclopropylglycine(155976-13-9)
• EPA Substance Registry System: Boc-L-cyclopropylglycine(155976-13-9)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 155976-13-9(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow solid

Uses

N-Boc-2-cyclopropyl-L-glycine is a useful synthetic compound.

InChI:InChI=1/C10H17NO4/c1-10(2,3)15-9(14)11-7(8(12)13)6-4-5-6/h6-7H,4-5H2,1-3H3,(H,11,14)(H,12,13)

Upstream product

• 638207-62-2 methyl 2-(N-tert-butoxycarbonylamino)-2-cyclopropylacetate 
• 768356-83-8 methyl 2-amino-2-cyclopropylacetate 
• 116611-45-1 (2R)-2-t-butoxycarbonylamino-3-phenylsulfonyl-1-(2-tetrahydropyranyloxy)propane 
• 4248-19-5 tert-butyl carbazate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 49606-99-7 (S)-2-amino-2-cyclopropylacetic acid 
• 765-43-5 Cyclopropyl methyl ketone 
• 155905-72-9 [(R)-1-(1-Benzenesulfonyl-cyclopropyl)-2-(tetrahydro-pyran-2-yloxy)-ethyl]-carbamic acid tert-butyl ester 
• 638207-64-4 methyl 2-(N-tert-butoxycarbonyl-N-chloroamino)-2-cyclopropylacetate 
• 936097-37-9 cyclopropyl-hydroxyiminoacetic acid 
• 475586-33-5 (S)-(1-cyclopropyl-3-phenyl-(E)-allyl)-carbamic acid tert-butyl ester 
• 15785-26-9 (S)-2-amino-2-cyclopropyl acetic acid 

Downstream Products

• 49606-99-7 (S)-2-amino-2-cyclopropylacetic acid 
• 138326-68-8 (S)methyl 2-amino-2-cyclopropylacetate hydrochloride 
• 1087348-18-2 (6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 
• 1087348-59-1 (2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one 

Relevant articles and documents

Ir-Catalyzed Enantioconvergent Synthesis of Diversely Protected Allenylic Amines Employing Ammonia Surrogates

The first iridium catalyzed, enantioconvergent amination of allenylic carbonates is reported. This process utilizes various commercially available carbamates and sulfonamides to generate allenylic amines including commonly employed protected groups (Boc, Fmoc, Cbz, Ts, Ns) in 62–82 % yield and 87–98 % ee. The products generated through this scalable procedure serve as effective linchpins for the rapid, enantiospecific synthesis of a wide range of complex structures.

Preparation of (S)-1-cyclopropyl-2-methoxyethanamine by a chemoenzymatic route using leucine dehydrogenase

(S)-1-Cyclopropyl-2-methoxyethanamine is a key chiral intermediate for the synthesis of a corticotropin-releasing factor-1(CRF-1) receptor antagonist. Resolution of the racemic amine by transaminase from Vibrio fluvalis gave a 38% yield of the S-amine wit

A general, highly enantioselective method for the synthesis of D and L α-amino acids and allylic amines

Catalytic and enantioselective synthesis of amino acids is a subject of intense interest in the field of asymmetric catalysis. Traditionally, researchers have concentrated their efforts largely on the design and discovery of enantiopure catalysts for the