155976-13-9

Usage

Uses

Used in Pharmaceutical Industry:
Boc-L-cyclopropylglycine is used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure allows for the creation of novel drugs with potential therapeutic benefits.
Used in Chemical Research:
In the field of chemical research, Boc-L-cyclopropylglycine serves as a valuable compound for studying the properties and reactions of cyclopropyl-containing molecules. It aids in understanding the behavior of such molecules in different chemical environments and their potential applications.
Used in Peptide Synthesis:
Boc-L-cyclopropylglycine is used as a building block in the synthesis of cyclic peptides. Its incorporation into peptide structures can lead to the development of new bioactive molecules with specific biological activities, such as antimicrobial, antiviral, or anticancer properties.
Used in Material Science:
In material science, Boc-L-cyclopropylglycine can be utilized in the development of novel polymers and materials with unique properties. Its cyclopropyl group may impart specific characteristics to the resulting materials, making them suitable for various applications, such as in coatings, adhesives, or plastics.
Used in Agricultural Chemistry:
Boc-L-cyclopropylglycine may also find applications in agricultural chemistry, where it can be used as a precursor for the synthesis of new pesticides or herbicides. Its unique structure could potentially lead to the development of more effective and environmentally friendly products.

InChI:InChI=1/C10H17NO4/c1-10(2,3)15-9(14)11-7(8(12)13)6-4-5-6/h6-7H,4-5H2,1-3H3,(H,11,14)(H,12,13)

Upstream product

• 475586-33-5 (S)-(1-cyclopropyl-3-phenyl-(E)-allyl)-carbamic acid tert-butyl ester 
• 638207-62-2 methyl 2-(N-tert-butoxycarbonylamino)-2-cyclopropylacetate 
• 936097-37-9 cyclopropyl-hydroxyiminoacetic acid 
• 765-43-5 Cyclopropyl methyl ketone 
• 15785-26-9 (S)-2-amino-2-cyclopropyl acetic acid 
• 768356-83-8 methyl 2-amino-2-cyclopropylacetate 
• 638207-64-4 methyl 2-(N-tert-butoxycarbonyl-N-chloroamino)-2-cyclopropylacetate 
• 116611-45-1 (2R)-2-t-butoxycarbonylamino-3-phenylsulfonyl-1-(2-tetrahydropyranyloxy)propane 
• 155905-72-9 [(R)-1-(1-Benzenesulfonyl-cyclopropyl)-2-(tetrahydro-pyran-2-yloxy)-ethyl]-carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 49606-99-7 (S)-2-amino-2-cyclopropylacetic acid 
• 4248-19-5 tert-butyl carbazate 

Downstream Products

• 138326-68-8 (S)methyl 2-amino-2-cyclopropylacetate hydrochloride 
• 1422128-79-7 C₂₅H₂₈F₆N₄O₂S 
• 1087348-18-2 (6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 
• 1087348-59-1 (2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one 

Relevant academic research and scientific papers

Ir-Catalyzed Enantioconvergent Synthesis of Diversely Protected Allenylic Amines Employing Ammonia Surrogates

The first iridium catalyzed, enantioconvergent amination of allenylic carbonates is reported. This process utilizes various commercially available carbamates and sulfonamides to generate allenylic amines including commonly employed protected groups (Boc, Fmoc, Cbz, Ts, Ns) in 62–82 % yield and 87–98 % ee. The products generated through this scalable procedure serve as effective linchpins for the rapid, enantiospecific synthesis of a wide range of complex structures.

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Preparation of (S)-1-cyclopropyl-2-methoxyethanamine by a chemoenzymatic route using leucine dehydrogenase

(S)-1-Cyclopropyl-2-methoxyethanamine is a key chiral intermediate for the synthesis of a corticotropin-releasing factor-1(CRF-1) receptor antagonist. Resolution of the racemic amine by transaminase from Vibrio fluvalis gave a 38% yield of the S-amine wit

Practical syntheses of both enantiomers of cyclopropylglycine and of methyl 2-cyclopropyl-2-N-Boc-iminoacetate

A facile three-step synthesis of racemic cyclopropylglycine in multigram quantities from inexpensive cyclopropyl methyl ketone has been elaborated. Enzymatic hydrolysis of the N-Boc-protected methyl ester of cyclopropylglycine 9 with the inexpensive enzyme papain from Carica papaya affords both enantiomers of cyclopropylglycine (8) with enantiomeric excesses of 99% or better after deprotection under acidic conditions. Furthermore, the new cyclopropyl group-containing building block methyl 2-cyclopropyl-2-N-Boc-iminoacetate (13) was prepared by N-chlorination and subsequent dehydrochlorination with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Addition of nucleophiles to 13 offers a ready access to an unusual, orthogonally bisprotected α,α-diamino acid derivative and interesting components of rigid peptide backbones.

A general, highly enantioselective method for the synthesis of D and L α-amino acids and allylic amines

Catalytic and enantioselective synthesis of amino acids is a subject of intense interest in the field of asymmetric catalysis. Traditionally, researchers have concentrated their efforts largely on the design and discovery of enantiopure catalysts for the

A Versatile Method for the Synthesis of (S)- or (R)-Cycloalkylglycines, (S)- or (R)-N-Heterocyclic and α,β-Unsaturated N-Heterocyclic α-Amino Acids

Two different types of cyclic α-amino acids, cycloalkylglycines and N-heterocyclic α-amino acids, were prepared in optically pure form from the same chiral synthon 1-(R) (or 1-(S)) simply by altering the quantity or type of base required for anion formation.Elaboration of the heterocyclic intermediate 3 provided α,β-unsaturated N-heterocyclic α-amino acids.