2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide

Base Information

Chemical Name:2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
CAS No.:161455-93-2
Molecular Formula:C₂₇H₂₈N₄O₄
Molecular Weight:472.544
Hs Code.:

Synonyms:2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide

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Chemical Property of 2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide

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Technology Process of 2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide

There total 5 articles about 2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2,4-dioxo-5-phenyl-3-(phenyl-hydrazono)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-yl]-N-isopropyl-N-(4-methoxy-phenyl)-acetamide

: 161455-93-2
2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide

Guidance literature:: With zinc; In methanol; acetic acid; ethyl acetate;

Reference yield:

: 16495-67-3
4-(isopropylamino)anisole

: 161455-93-2
2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: DIPEA / CH₂Cl₂ / cooling

2: K₂CO₃ / dimethylformamide / 20 °C

3: 8.4 g / tetrahydrofuran / 16 h / 20 °C

4: 93.7 percent / zinc; glacial acetic acid / 20 °C

With potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049072h

Reference yield:

: 104-94-9
4-methoxy-aniline

: 161455-93-2
2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium triacetoxyborohydride

2: DIPEA / CH₂Cl₂ / cooling

3: K₂CO₃ / dimethylformamide / 20 °C

4: 8.4 g / tetrahydrofuran / 16 h / 20 °C

5: 93.7 percent / zinc; glacial acetic acid / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049072h