(R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

Base Information

Chemical Name:(R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester
CAS No.:1370415-95-4
Molecular Formula:C₂₀H₂₃NO₃
Molecular Weight:325.408
Hs Code.:

Synonyms:(R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

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Chemical Property of (R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

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Technology Process of (R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

There total 1 articles about (R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 42288-46-0
(3,5-dimethylphenyl)acetic acid

: 13033-84-6
D-phenylalanine methyl ester hydrochloride

: 1370415-95-4
(R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

Guidance literature:: (3,5-dimethylphenyl)acetic acid; With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

D-phenylalanine methyl ester hydrochloride; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield: 98.0%

: 1370415-95-4
(R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

: 1276021-01-2
(R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid

Guidance literature:: (R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester; With sodium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 1370415-95-4
(R)-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

: 1356955-71-9
(R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-dimethylphenyl)acetamido]-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 1 h / 20 °C

1.2: pH 2

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.10.051