4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone

Base Information

Chemical Name:4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone
CAS No.:87791-60-4
Molecular Formula:C₂₃H₂₉N₂O₆P
Molecular Weight:460.467
Hs Code.:

Synonyms:4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone

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Chemical Property of 4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone

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Technology Process of 4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone

There total 3 articles about 4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 538-37-4
dibenzyl phosphochloridate

: 80582-03-2
(3S-trans)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-methyl-2-azetidinone

: 87791-60-4
4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1139/v83-296

Reference yield:

: 75659-16-4
(3S-trans)-3-[(t-Butyloxycarbonyl)amino]-4-methyl-2-oxo-1-(phenylmethoxy)azetidine

: 87791-60-4
4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 760 Torr

2: 43 percent / 3 N NaOH, 15percent aq. TiCl₃ / methanol; H₂O / 3 h

3: 60 percent / n-BuLi / tetrahydrofuran / 1 h / -78 °C

With sodium hydroxide; n-butyllithium; titanium(III) chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1139/v83-296

Reference yield:

: 80542-48-9
(3S-trans)-3-(t-butyloxycarbonylamino)-1-hydroxy-4-methyl-2-azetidinone

: 87791-60-4
4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / 3 N NaOH, 15percent aq. TiCl₃ / methanol; H₂O / 3 h

2: 60 percent / n-BuLi / tetrahydrofuran / 1 h / -78 °C

With sodium hydroxide; n-butyllithium; titanium(III) chloride; In tetrahydrofuran; methanol; water;
DOI:10.1139/v83-296