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Usage

Uses

Used in Pharmaceutical Industry:
(3S-trans)-3-(t-butyloxycarbonylamino)-1-hydroxy-4-methyl-2-azetidinone is used as a pharmaceutical compound for its potential medicinal properties. Its unique structure and functional groups may contribute to the development of new medications or the enhancement of existing ones, particularly in the synthesis of other pharmaceutical compounds where its specific molecular features can be leveraged for therapeutic benefits.
Used in Organic Synthesis:
In the field of organic synthesis, (3S-trans)-3-(t-butyloxycarbonylamino)-1-hydroxy-4-methyl-2-azetidinone is used as a key intermediate or building block in the creation of more complex organic molecules. Its functional groups can participate in various chemical reactions, facilitating the synthesis of a wide range of organic compounds for different applications, including but not limited to pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 75659-16-4 (3S-trans)-3-[(t-Butyloxycarbonyl)amino]-4-methyl-2-oxo-1-(phenylmethoxy)azetidine 

Downstream Products

• 993-13-5 methylphosphonic acid 
• 87791-60-4 4-methyl-3-<(tert-butoxycarbonyl)amino>-1-dibenzylphosphoryl-2-azetidinone 

Relevant academic research and scientific papers

2-oxoazetidin-1-yloxy acetic acids and analogs

Antibiotic activity is exhibited by β-lactams having an STR1 substituent (and analogs thereof) in the 1-position and an acylamino substituent in the 3-position.

Crystalline anhydrous aztreonam

The crystalline anhydrous form of [3S-[3α(Z), 4β]]-3-[[(2-amino-4-thiazolyl) [(1-carboxy-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid is prepared.

2-OXO-1-AZETIDINESULFONIC ACID SALTS

Antibacterial activity is exhibited by beta-lactams having a sulfonic acid salt substituent in the 1-position and an amino or acylamino substituent in the 3-position.

3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters

Antimicrobial activity is exhibited by β-lactams having a STR1 substituent in the 1-position and an acylamino substituent in the 3-position, or a pharmaceutically acceptable salt thereof; wherein Y is oxygen or sulfur and R5 is hydroxyl, alkyl, substituted alkyl, phenyl, substituted phenyl, alkoxy, alkylthio, (substituted alkyl)oxy, (substituted alkyl)thio, phenyloxy, phenylthio, (substituted phenyl)oxy or (substituted phenyl)thio.

2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines

Antibacterial activity is exhibited by β-lactams having a STR1 substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5

REARRANGEMENT OF N-HYDROXY-2-AZETIDINONES TO 5-ISOXAZOLIDINONES

N-Hydroxy-2-azetidinones (IV) underwent a new rearrangement to 5-isoxazolidinones (V).By use of this rearrangement, one (Ve) of isomers of cycloserine was synthesized.