4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane

Base Information

• Chemical Name: 4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane
• CAS No.: 859204-84-5
• Molecular Formula: C₁₆H₂₆F₂
• Molecular Weight: 256.379
• Mol file: 859204-84-5.mol

Synonyms:4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane

Chemical Property of 4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane

There total 2 articles about 4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4'-propylcyclohexyl)-1-trifluoromethylcyclohexane (859204-86-7,133261-31-1) → 4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane (859204-84-5)

Guidance literature:

With potassium tert-butylate; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; at -10 - 20 ℃; for 0.666667h; Product distribution / selectivity;

Reference yield:

dibromodifluoromethane (75-61-6) + 4-(trans-4-n-propylcyclohexyl)cyclohexanone (82832-73-3) → 4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane (859204-84-5)

Guidance literature:

With hexaethylphosphoric triamide;

DOI:10.1080/15421400490434919

Reference yield:

4-(4'-propylcyclohexyl)-1-difluorovinylcyclohexane (859204-84-5) → 4-[(3,4-difluoro-phenoxy)-difluoro-methyl]-4'-propyl-bicyclohexyl (208531-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂

2: K₂CO₃ / dimethylformamide

3: H₂ / Pd/C

With hydrogen; bromine; potassium carbonate; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1080/15421400490434919

upstream raw materials:

dibromodifluoromethane

4-(trans-4-n-propylcyclohexyl)cyclohexanone

4-(4'-propylcyclohexyl)-1-trifluoromethylcyclohexane

Downstream raw materials:

4-[(3,4-difluoro-phenoxy)-difluoro-methyl]-4'-propyl-bicyclohexyl

4-[difluoro-(3,4,5-trifluoro-phenoxy)-methyl]-4'-propyl-bicyclohexyl

Refernces

• 1、 Matsui, Shuichi,Kondo, Tomoyuki,Sago, Kouki. "Synthesis and properties of novel liquid crystalline compounds having a difluoromethyleneoxy moiety as a linkage group". . p. 127/[1169]-137/[1179]. Retrieved 2007/10/03.